Professor Lampson Fan

Qualifications

MA (Cantab), MB Bchir, Dphil (Oxon), MRCP

GMC number: 6154866

Practising since: 2007

Specialties

Cardiology

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About

Dr Lampson Fan graduated from University of Cambridge with Honors in 2007. Following achievement of his Dphil at University of Oxford in Cardiovascular Medicine, he completed his Interventional Cardiology Training in 2019 with further training in a competitive fellowship at Freeman Hospital in Newcastle. He started as a substantive Interventional cardiology consultant at Royal Wolverhampton NHS Trust in 2020.

His main clinical interest is complex coronary intervention with high volumes performed including left main stem, calcium modification such as rotational atherectomy and shockwave lithotripsy, left ventricular assist device and chronic total occlusions.

His main research interest currently is microvascular disease and endothelial dysfunction in vascular diseases with numerous high impact publications in these areas. He was appointed as Associate Honorary Professor at University of Birmingham in recognition of his academic achievements.

Dr Fan is also passionate about education with a special focus on simulation. He is the educational lead for cardiology and was recently appointed as the Medical Simulation Lead for Aston University Medical School.

Outside of work Dr Lampson Fan is a keen snowboarder and martial artist.

Special interests

Complex Intervention

Coronary Physiology

Microvascular disease


Other interests

Education especially simulation


Locations Professor Lampson Fan works with

Related experience

Research

2023 - Intra-coronary physiology in contemporary percutaneous coronary intervention and anginal therapy with a focus on microvascular disease. Zaheer Alisiddiq, Harish Sharma, James Cotton, Lampson Fan. Front. Cardiovasc. Med., 29 November 2023, Volume 10, 2023. https://doi.org/10.3389/fcvm.2023.1255643

2022 - T Jinadu; A Radhakrishnan, L Fan, Improving use of proton pump inhibitors with dual anti-platelet therapy in patients admitted with acute coronary syndrome. BMJ Open Quality 2022 Dec;11(4):e001956. doi: 10.1136/bmjoq-2022-001956..

2022 - Fan LM, Liu F, Du J, Geng L, Li JM. Inhibition of endothelial Nox2 activation by LMH001 protects mice from angiotensin II-induced vascular oxidative stress, hypertension and aortic aneurysm. Redox Biol. 2022 May;51:102269. doi: 10.1016/j.redox.2022.102269. Epub 2022 Mar 3. PMID: 35276443; PMCID: PMC8908273.

2021 - Liu F, Fan LM, Geng L, Li JM. p47phox-Dependent Oxidant Signalling through ASK1, MKK3/6 and MAPKs in Angiotensin II-Induced Cardiac Hypertrophy and Apoptosis. Antioxidants (Basel). 2021 Aug 26;10(9):1363. doi: 10.3390/antiox10091363. PMID: 34572995; PMCID: PMC8468498.

2021 - Hannah Sinclar, Lampson Fan, Mamas Mamas, Javed Ahmed. IVUS guided intra-coronary shockwave lithotripsy: First Real world experience. Health Science Reports; https://doi.org/10.1002/hsr2.307

2020 - Sunbal Bhatti, Lampson Fan, Adam Collins, et al. Exploration of Alcohol Consumption Behaviours and Health-Related Influencing Factors of Young Adults in the UK. Int. J. Environ. Res. Public Health 2020, 17(17), 6282; https://doi.org/10.3390/ijerph17176282

2020 - Lampson Fan, David Tong, Gary Mintz, Mamas Mamas, Javed Ahmed. Breaking the deadlock of calcified coronary artery lesions: a contemporary review. Catheterization & Cardiovascular Interventions, https://doi.org/10.1002/ccd.29221

2020 - Fangfei Liu, Lampson M Fan, Nicholas Michael, Jian-Mei Li. In vivo and in silico characterisation of apocynin in reducing organ oxidative stress: a pharmacokinetic and pharmacodynamic study. Pharmacol Res Perspect. 2020 Aug;8(4):e00635. doi: 10.1002/prp2.635.

2020 - Fan, L.M., Collins, A., Geng, L. et al. Impact of unhealthy lifestyle on cardiorespiratory fitness and heart rate recovery of medical science students. BMC Public Health 20, 1012 (2020). https://doi.org/10.1186/s12889-020-09154-x

2020 - Lampson Fan, Andrew Lucking, Andrew Kelion, Nikant Sabharwal, Jeremy Langrish. Aortic pseudoaneurysm with compression of left main stem following aortic valve replacement. Canadian Journal of Cardiology. 2020 Jun;36(6):968.e-9-968.e11.

2019 - Roberto Scarsini, MD; Giovanni L. De Maria, MD, PhD; Jubin Joseph, MD, PhD; Lampson Fan, MD, PhD; Thomas J. Cahill, MD, DPhil; Rafail A. Kotronias, MBChB, MSc; Francesco Burzotta, MD; James D. Newton, MD, PhD; Rajesh Kharbanda, MD, PhD; Bernard Prendergast, MD, FRCP; Flavio Ribichini, MD; Adrian P. Banning, MD, FRCP. Impact of complications during transfemoral transcatheter aortic valve replacement: How can they be avoided and managed? Journal of the American Heart Association. 2019 Sep; 8:e013801

2019 - Lampson M Fan*, Li Geng*, Sarah Cahill-Smith, Fangfei Liu, Gillian Douglas, Chris-Anne Mckenzie, Colin Smith4, Gavin Brooks, Keith Channon, Jian-Mei Li. Endothelial Nox2 activation and brain oxidative damage in aging. Journal of Clinical Investigations. 2019 Aug; 129(8): 3374-3386.

2019 - Evangelos K. Oikonomou MD, Michelle C. Williams MD PhD, Christos P. Kotanidis MD MSc, Milind Y. Desai MD, Mohamed Marwan MD, Alexios S. Antonopoulos MD PhD, Katharine E. Thomas MBBS MRCP, Sheena Thomas BSc, Ioannis Akoumianakis MD, Lampson M. Fan MRCP Dphil et al. A novel machine learning-derived radiotranscriptomatic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography. European Heart Journal. 2019 DOI:10.1093/eurheartj/ehz592

2019 - Asad Shabbir, Lampson Fan, Gregory Fraser, Mark Cassar, Jon Swinburn. Quantification of ischaemia of prognostic mandate for coronary revascularization in asymptomatic patients: how much is enough. In press. Critical pathways in Cardiology. 2019 Jun;18(2):98-101.

2019 - Asad Shabbir, Lampson Fan, Gregory Fraser, Mark Cassar, Jon Swinburn. One-hour high sensitivity troponin testing: A safe and effective triage tool for the emergency department. In press. Critical pathways in Cardiology 2019 Mar;18(1):16-18.

2017 - L.M. Fan, Sarah Cahill-Smith, Li Geng; Junjie Du, Gavin Brooks, Jian-Mei Li. Glucose metabolic disorder induced Nox2 activation and oxidative damage of endothelial function in aging. Free Radic Biol Med. 2017 May 10;108:940-951.

2016 - Meijles D.N., L.M. Fan, M.M. Ghazaly, B. Howlin, M. Krönke, G. Brooks and J-M. Li. p22phox C242T SNP inhibits inflammatory oxidative damage to endothelial cells and vessels. Circulation 2016, doi: 10.1161/CIRCULATIONAHA.116.021993

2014 - Fan, L.M., G. Douglas, J.K. Bendall, E. McNeill, M. J. Crabtree, A.B. Hale, A. Mai, J-M. Li, M.A. McAteer, J.E. Schneider, R.P. Choudhury, and K.M. Channon. Endothelial cell specific ROS production increases susceptibility to aortic dissection. Circulation 2014;129:2661-2672

2014 - Fan, L. and B. Prendergast, N. Herring. Current controversies in infective endocarditis. EMJ Cardio. 2014;2:105-113

2014 - Fan, L. and JM Li. Evaluation of methods for detecting reactive oxygen species production for drug screening and cell cycle studies. J. Pharmacol. Toxicol. Methods. doi: 10.1016/j.vascn.2014.03.173

2014 - Harston G.W.J., F. Batt, L. Fan, T.W. Okell, F. Sheerin, T. Littlewoord and J. Kennedy. Lacunar infarction associated with anabolic steroids and polycythemia: A case report. Case Rep Neurol 2014;6:34-37 (doi:10.1159/000360076)

2013 - Du, J., L.M. Fan, A. Mai, and J-M. Li. Critical roles of Nox2-derived oxidative stress in deteriorating the function of insulin receptors and endothelium in dietary obesity of middle-aged mice. . 2013 Nov;170(5):1064-77. doi: 10.1111/bph.12336.Br J Pharmacol

2012 - Teng, L., L.M. Fan, D. Meijles and J-M. Li. Divergent effects of p47 (phox) phosphorylation at S303-4 or S379 on tumour necrosis factor-α signalling via TRAF4 and MAPK in endothelial cells. Arterioscler Thromb Vasc Biol. 2012 Jun;32(6):1488-96.

2011 - Tickner, J., L.M. Fan, J. Du, D. Meijles and J-M. Li. Nox2-derived ROS in PPARγ signaling and cell-cycle progression of lung alveolar epithelial cells. Free Radic Biol Med. 2011;51:763-72

2009 - Fan L., L. Teng, and J-M. Li. Knockout of p47phox uncovers a critical role of p40phox in reactive oxygen species production in microvascular endothelial cells. Arterioscler Thromb Vasc Biol. 2009;29(10):1651-6

2009 - Fan L., D. Sawbridge, V. George, L. Teng, A. Bailey, I. Kitchen, and J-M. Li. Chronic cocaine induced Cardiac oxidative stress and MAPK activation: The role of Nox 2 oxidase. J. Pharmacol. Exp. Ther. 2009;328:99–106.

2009 - Kunal Gupta, Fan L. Doctors: couch potatoes or fighting fit? A multi-centre study. Br J Sports Med. 2009;43:153-154.

2007 - Li JM., L.M. Fan, V.T. George, and G. Brooks. Nox2 regulates endothelial cell cycle arrest and apoptosis via p21cip1 and p53. Free. Rad. Biol. Med. 2007;43:976-986.

2005 - Li JM, L.M. Fan, M.R. Christie and A.M. Shah. Acute TNFα signaling via NADPH oxidase in microvascular endothelial cells: Role of p47phox phosphorylation and binding to TRAF4. Mol. Cell. Biology 2005;25:2320-2330.

2004 - Li JM., S. Wheatcroft, L.M. Fan, M.T. Kearney and A.M. Shah. Opposing roles of p47phox in basal versus angiotensin II-stimulated alterations in vascular O2.- production, vascular tone and mitogen-activated protein kinase activation. Circulation. 2004; 109:1307-1313

2003 - Li, J-M, L.M. Fan and G. Brooks. Targeting αvβ3 and α5β1 integrins for gene delivery to vascular smooth muscle cells in vitro and ex-vivo-synergistic effect of TGFβ1. Am J Physiol Heart Circ Physiol 2003;285:H1123-H1131.

Memberships

  • MRCP

Other posts held

  • Royal Wolverhampton NHS Trust, Consultant Interventional Cardiologist